When the stress is turned on, ATF-2 changes its function and induces Inheritance of Stress-Induced, ATFDependent Epigenetic Change. A typical example of epigenetics is DNA methylation, which is important for . ATF‐2 is a target of the stress‐activated protein kinase p Recently .. Inheritance of dATF‐2‐dependent, stress‐induced epigenome change. Alterations to epigenetic states allow the organism to adapt to Inheritance of stress-induced, ATFdependent epigenetic change. Cell
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The results suggest a mechanism by which the effects of stress are inherited epigenetically via the regulation of a tight chromatin structure.
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When embryos were exposed to heat stress over multiple generations, the defective chromatin state was maintained over multiple successive generations, though it gradually returned to the normal state.
Heat shock or osmotic stress induced phosphorylation of dATF-2 and resulted in its release from heterochromatin. This heterochromatic disruption was an epigenetic event that was transmitted to the next generation in a non-Mendelian fashion.
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Inheritance of stress-induced, ATFdependent epigenetic change.
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Recommend to your librarian. Don’t have an account? I am an author of this article. The dATF-2 protein colocalized with HP1, not only on heterochromatin but also at specific loci in euchromatin. You are a close professional associate of any of the authors e.
Inheritance of stress-induced, ATF-2-dependent epigenetic change.
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