Diazotization Titration or Nitrite Titration. Diazotization is used in the analysis of aromatic compounds containing an amino group in the. View Notes – from ECH at University of Florida. Diazotization titration (Nitrite Titration) Mr. V. M. Patil Assistant Professor & PG. Quantitative estimation of Eflornithine by Nitrite (Diazotization) titration Here the amino group of Eflornithine is diazotized with sodium nitrite solution in.
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Pharmaceutical Analysis by P. D. Chaithanya Sudha
Maintenance of the temperature is the main condition for the diazotization titration. This readily undergoes the coupling reaction with the nitrous acid. The diazotization titration is nothing but the conversion of the primary aromatic amine to titratikn diazonium compound. What is a chemical reaction? The end point is determined by the above-mentioned methods. What are the example drugs assayed by the diazotization titrimetry?
When sodium nitrite is reacted with the hydrochloric acid sodium chloride and nitrous acid are formed. Chapter 3 Chemical reactions. Used in the determination of the sulphonamides. With Safari, you learn the way you learn best. Applicable for a very less variety of titratlon. Based on this, the amino compounds are classified into two main groups. The steps involved in the non-aqueous titrimetric method are proposed doazotization the Tomicek.
A Seminar on Potentiometric and Diazotization Titrations – ppt video online download
This method is first used in the determination of dyes. The reaction mechanism was diazotizzation proposed by Peter Griessin. Unknown 6 December at May be used for the analysis of drugs such as benzocaine, dapsone, primaquine etc.
The end point detection is very difficult. The end point is detected by the formation of the blue colour with starch iodide paper. Another procedure is—after maintaining the conical flask temperature, the pair of platinum electrodes is immersed.
Analytical Chemistry Volumetric Analysis.
These are extremely weak and cannot be analysed using normal titrimetric methods. This is prepared by immersing the filter paper in the starch mucilage and potassium iodide solution.
For example, the aminophenol is readily oxidized by the nitrous acid and converted to the quinones in the presence of copper sulphate solution and forms the diazo oxide compounds. The accurately weighed sample is added to the 5 ml of HCl and 50 ml of distilled water.
Used in the determination of the amphetamine. The electrode assumes a potential proportional to the logarithm of concentration ratio of the two oxidation states of the reactant or the titrant which ever is capable of properly poising the electrodes.
Rejuvenation required over a period of time to avoid any errors. Used in the determination of the P -amino benzoic acid vitamin B 4. About project SlidePlayer Terms of Service.
Activity not concentration Concepts to review: Fritz first used this method to distinguish the aromatic and aliphatic amines by using the perchloric acid as titrant. The main principle involved in this method is the formation of the diazo oxide which is more stable than the diazo compounds. Hence the non-aqueous titrimetric method is used.
Used in the determination of the procaine. The reaction rate is increased by the addition of the potassium bromide solution. What is the principle involved in the diazotization titrimetry? The percentage amount of the sulpha drug is determined by the following equation: Registration Forgot your password?
Then concentrated hydrochloric acid and potassium bromide are added and the rest of the volume is filled with the distilled water. This method is mainly used for the titration of insoluble diazonium salts.
What are the conditions required for the diazotization titrimetry? Sulphanilic acid and anthranilic acid. Selective for the all types of sulphonamides. In non-aqueous titrations, usually, the milli volt scale of potentiometer is used rather than pH scale since the potential of the non-aqueous systems exceed the pH diazottization.