BCR 503 DATASHEET PDF

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The Selleck dilution calculator is based on the following equation:. Dilution Calculator Dilution Calculator Calculate the dilution required to prepare a stock solution.

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Not for human use. Serial Dilutions Concertration start: In vivo MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice. To calculate molar mass of a chemical compound, please enter its chemical formula and click ‘Calculate’.

The Selleck molarity calculator is based on the following equation:. Bio Calculators Molarity Calculator Molarity Calculator Calculate the mass, volume or concentration required for a solution. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Molecular mass dahasheet weight is the mass of one molecule of a substance and is expressed in the unified dstasheet mass units u. Histone Methyltransferase Signaling Pathway Map. Calculate the mass, volume or concentration required for daatsheet solution. Prolonged treatment 38 days with MI induces no toxicity in mice as reflected by no alterations in the body weight and no morphological changes in liver and kidney tissues.

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The cell growth inhibitory effect of MI is time-dependent, with a pronounced effect achieved after days of treatment. The Selleck dilution calculator is based on the following equation: Menin-MLL interaction [1] Cell-free assay. Chemical formula is case sensitive.

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Products are for research use only. MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice. For cell differentiation studies, leukemia cells are treated with menin-MLL inhibitors for 7 days, then harvested, washed and incubated with Pacific Blue rat anti-mouse CD11b antibody before dtasheet analyzed by flow cytometry.

We do not sell to patients. MI could substantially improve survival of MLL leukemic mice and does not impair normal hematopoiesis in vivo [1]. Molecular Weight Calculator Molecular Weight Calculator Enter the chemical formula of a compound to calculate its molar mass and elemental composition: Treatment with sub-micromolar concentrations of MI also leads to markedly reduced expression of Hoxa9 and Meis1, downstream targets of MLL fusion proteins substantially upregulated in MLL leukemias [1].

These effects are accompanied by reduced c-kit CD expression, a marker associated with leukemia stem cells LSCs. References [1] Borkin D, et al. It blocks hematologic tumors in vivo and reduces MLL leukemia tumor burden. This is normal and is due to slight batch-to-batch variations. Br Selleck molarity calculator is based on the following equation: Answers to questions you may have can be found in the inhibitor handling instructions. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines GI50 at nM nM rangebut only a minimal effect in human leukemia cell lines without MLL translocations.

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Calculate the dilution required to prepare a stock solution.

MI is also very effective in inducing differentiation of MLL leukemia cells and substantially increases expression of CD11b, a myeloid differentiation marker. Choose Selective Histone Methyltransferase Inhibitors. Media is changed at day 4, viable cell numbers are restored to the original concentration and compounds are re-supplied.

Tech Support Answers to questions you may have can be found in the inhibitor handling instructions. This equation is commonly abbreviated as: For viability assays, leukemia cells are plated at relevant concentrations and treated with compounds or 0.